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As with any skincare product, it's advisable to perform a patch test before full application to ensure compatibility with your skin

What Has Not Been Established It has not been proven universally superior to reduced glutathione

Nevertheless, when administered topically alongside other lightening agents, it can be a safe option for those dealing with pigmentation or melasma

However, as DR progresses, retinal vascular changes increase not only in number and severity, and tend to spread to the central retina where they can involve the macula, the region of the retina that underlies high acuity vision (Figure 6)