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J Pediatr 1983;102:931-5

Neurodegenerative diseases Neurons cannot dilute damaged organelles and cellular waste through cell division, implying the great need for an efficient intracellular clearance system 121,122

In addition, calcium fluctuations weaken the interaction between hemoglobin and the membrane, encouraging hemoglobin to shift into the cytoplasm ( Mg 2+ acts as a cofactor for Ca 2+ -ATPase, boosting pump activity to help maintain low intracellular Ca 2+ levels and preventing membrane calcification ( 2+ influences the assembly and organization of the erythrocyte cytoskeleton, which is primarily composed of actin and spectrin

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