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Evidence from observational studies suggests that with longer symptom duration and more profound B 12 deficiency, the likelihood that neurological symptoms will not completely resolve increases.28 People often continue to experience mild neurological symptoms such as poor memory, impaired concentration, and fatigue even after adequate B 12 replacement (eg, therapy according to the BNF suggested treatment regimen)91729 and many patients report they need additional treatment

Nonetheless, further research is required to comprehensively understand the safety and efficacy of these materials in the eye

10.1016/j.cellsig.2024.111531 135 ZhaoM.WangY.LiL.LiuS.WangC.YuanY.et al (2021)

However, even if the microarray and karyotype come back negative, genetics may still be involved