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[116] This natural increase suggests that melatonin plays important physiological roles during pregnancy, including potential effects on fetal development, maternal circadian rhythms, and pregnancy outcomes

Hematocrit, reticulocyte count, vitamin B 12 , folate, and iron levels should be obtained prior to treatment

Precision targeting of PTMs remains challenging: Although specific phosphorylation sites and ubiquitination patterns are known to regulate NRF2 stability, developing modifiers that selectively target these modifications without affecting other pathways is technically demanding

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