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Indeed, in a recently completed Phase I trial of APR-246 in patients with haematological malignancies, it was noted that the addition of APR-246 to a patient receiving concurrent sorafenib resulted in complete remission of their acute myeloid leukaemia 35

In fact, the high expression of glycogen synthase-1 in RA-FLSs can lead to the excessive accumulation of glycogen and inhibit AMPK expression, leading to the high expression of matrix metallopeptidase (MMP)-1, MMP-9, IL-6, and CCL-2, along with increased proliferation and migration of FLSs

Nitric oxide modulates the expression of endothelial cell adhesion molecules involved in angiogenesis and leukocyte recruitment

Xiao M, Yang H, Xu W, Ma S, Lin H, Zhu H et al