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Similarly, the BiG mice, while sharing changes with 5xFAD, also display defective U1 snRNP splicing components similar to N40K 9 , and uniquely present lipid and synaptic dysregulation that may be due to the synergy of amyloid and U1 snRNP pathways 64 (Fig

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BPC-157 is used in cell-based assay research examining its interactions with growth factor receptor signalling pathways, including FAK-paxillin pathway activation and downstream phosphorylation events