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Of note, all key events in APAP- and other metabolism-targeting agents-induced liver damage, including catabolic processes, autophagy, mitochondrial morphology, cellular respiration, and oxidative stress, are strongly interconnected and strikingly involve the contribution of several BCL-2 proteins (Supplementary Fig

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The extract displayed dose- and time-dependent antiproliferative effects on A549 cells, with IC 50 decreasing from 340.63 g/mL at 24 h to 107.08 g/mL at 72 h, indicating enhanced cytotoxicity over time

Genomic duplication and overexpression of TJP2/ZO-2 leads to altered expression of apoptosis genes in progressive nonsyndromic hearing loss DFNA51