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[65] synthesized a novel pH-sensitive nanomedicines of Dex based on an N-(2-hydroxypropyl)methacrylamide copolymer (P-Dex)

Vial Size by Protocol Tolerance testing: A 2mg or 5mg vial is the smallest unit cited 1-3 weeks at standard doses Standard 200mcg/day pre-bedtime protocol: 5mg vial 25 days, fits the stability window The most-cited size in vendor sales data 1-2 vials per month Extended cycles: 10mg 5 kit drops cost to $4.40-10/mg Each vial reconstituted only when needed

Proteomics data are available via ProteomeXchange with the identifier PXD042314 ( Abbreviations ASD: autism spectrum disorders CNS: central nervous system CGI: Clinical Global Impression DEGs: differentially expressed genes DEPs: differentially expressed proteins EV: extracellular vesicles FC: fold change GCP: Good Clinical Practice GO-BP: Gene Ontology-Biological Process GSEA: Gene Set Enrichment Analysis IRB: Institutional Review Board LR: ligandreceptor LCMS/MS: liquid chromatography tandem mass spectrometry MCID: minimal clinically important difference NK: natural killer NTA: nanoparticle tracking analysis PBMCs: peripheral blood mononuclear cells PBS: phosphate-buffered saline PD: Proteome Discoverer pDCs: Plasmacytoid dendritic cells PHGDH: Phosphoglycerate dehydrogenase SEM: standard error of the mean TADA: Transmission and de novo Association WGCNA: Weighted gene co-expression network analysis References Maenner, M

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