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Unlike other drugs such as Mounjaro and Zepbound, which activate both GLP-1 and GIP receptors, MariTide works as a GLP-1 receptor agonist and a GIP receptor antagonist

Always titrate from the lowest dose to manage GI tolerability

This NAD+ elevation activates sirtuins (particularly SIRT1), enhances mitochondrial function, and preserves methylation capacity by reducing S-adenosylmethionine (SAM) consumption

Benefit #2: Reversal of Diet-Induced Obesity (Strong Evidence) Evidence Quality: Multiple animal studies with consistent results Mechanism: Improved fat oxidation and reduced adipocyte size 5-Amino-1MQ demonstrates powerful effects against obesity in research models