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Chen M, Wang F, Cao JJ, Han X, Lu WW, Ji X, Chen WH, Lu WQ, Liu AL (2019) ()-Epigallocatechin-3-gallate attenuates the toxicity of methylmercury in Caenorhabditis elegans by activating SKN-1

While the full GSH molecule has been simulated in solution, chemical modifications were only encountered on the cysteine moieties of this biomolecule, in particular at the thiol group

However, excessive/insufficient mitophagy, inhibition of mitochondrial biogenesis, and an overall reduction in protein synthesis can lead to mitochondrial dysfunction, causing insufficient ATP production or an increased burden of ROS, which in turn cannot meet the cellular demands, ultimately leading to energy deprivation and cell death