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3 Results 3.1 DSF and RF targets DSF was predicted to target 113 protein molecules in SuperPred, 10 in STITCH, 99 in DIGEP-Pred (51 were downregulated and 48 were upregulated), 13 in BindingDB, and 52 from published literature

Variants in TP53 (rs1042522), particularly the Pro allele, are linked to impaired apoptotic function and heightened NPC risk, while MDM2 (rs2279744) facilitates p53 degradation, further driving tumor progression (31)

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Tolerance is generally goodstart low and increase gradually to assess GI comfort