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Finally, the proteins are moved into the lysosomal lumen and degraded with the help of other chaperones, such as lysosomal (Lys)-heat shock cognate protein 70 [9]

Randomized clinical trial on the effect of bardoxolone methyl on GFR in diabetic kidney disease patients (TSUBAKI study)

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Many factors are involved in regulating ASCT2 expression, including the transcription factors c-Myc, RNF5, Leptin, and Insulin (Van Geldermalsen et al., 2016)