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A notable increase in ORMDL3 expression, increased expression of epithelial-mesenchymal transition (EMT)-related markers, including E-cadherin, vimentin, and fibroblast-specific protein 1 (FSP-1), and a positive correlation with the severity of airway remodeling was observed in the OVA-induced mice model (122)

In contrast, metformin is commonly used during pregnancy for diabetes and polycystic ovary syndrome, and is compatible with breastfeeding

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More notably, they highlight that competition between lactylation and acetylation may arise directly from shared catalytic machinery: When multiple acyl-CoA species coexist in the nucleus, they may compete for occupancy of the same acyl-CoA channel within p300, thereby influencing the balance between distinct PTMs