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The excessive increase of reactive oxygen species (ROS) leads to an increase in levels of Ca +2 ions, which play a critical role in the initiation and propagation of seizure, as well as results in the entry of the neurotoxin and inflammatory cells, which are considered mediators of seizure (DeLorenzo et al., 2006)

This work was supported by grants from the Key Laboratory of Traditional Chinese Medicine Classical Theory and 2023 Qilu Biancang Chinese Medicine Talent Training Program

Variance among all groups was not statistically different