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Following previous suggestions from the reviewer, to strengthen this aspect of the study, we performed two relevant and demanding experiments: (1) a new experiment using 30 additional adult mice to genetically label and quantify the newly formed OLs in the lesion area, using the pro-myelinating compound clemastine as positive control

The parent peptide has a plasma half-life of only 2 to 5 minutes

Reclast is contraindicated in patients with creatinine clearance less than 35 mL/min and in those with evidence of acute renal impairment