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Metabolites as FMT Active Agents The broad range of metabolites in fecal material, encompassing significant antioxidant, redox-modulating, and anti-inflammatory functions, increasingly points to the vital role of metabolites and other non-live, microbiome-derived molecules in FMT efficacy

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Furthermore, as mentioned earlier, under certain circumstances, low oxygen conditions lead to dimer formation between BMAL1 and HIF-1, which then bind with HREs for transcriptional activation