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53 MD is a fatal disorder, and affected patients usually die in early childhood

If pro-inflammatory insults occur during this key period of maturation, such as the intermittent-hypoxic events that preterm infants may experience, then diversion of microglia into the M1 pro-inflammatory state could cause neural damage

Conversion of glutamate + pyruvate to -ketoglutarate + alanine in the presence of PLP is consistent with the established alanine aminotransferase (ALT) reaction mechanism (Fig