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doi: 10.1002/jgm.1334 179 ArrigoniPRuprechtJCChasseDADGlassKAAndressBGuilakFet al

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thaliana, Hordeum vulgare, Oryza sativa, Physcomitrella patens, Pinus tabulaeformis, Populus trichocarpa , and Solanum lycopersicum ) and selecting only proteins possessing the two regular N- and C-terminal domains (see below), led to the identification of 14 GST classes: phi (F), tau (U), theta (T), zeta (Z), lambda (L), hemerythrin (H), iota (I), ure2p, glutathionyl-hydroquinone reductase (GHR), elongation factor 1B gamma (EF1B), DHAR, tetrachlorohydroquinone dehalogenase (TCHQD), metaxin, and microsomal prostaglandin E synthase type-2 (mPGES-2) (Lallement et al., 2014)

Although xCT expression is confined to the plasma membrane in normal tissues (36,39), it is upregulated in certain types of cancer, such as colorectal cancer, malignant glioma and non-small cell lung cancer, which increases cystine uptake (4042)