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Finally, although the correlations between the metabolome and microbiome were established using robust statistical analyses, there was limited statistical power and there are also limitations to the statistical approaches used herein (e.g., log transformation to resolve non-normal distribution and/or heteroscedasticity 103 )

Unlike trigeminal neuralgia, which involves short (seconds to minutes) episodic, sharp, electric-like pain affecting one or more branches of the trigeminal nerve, CTN often manifests as continuous pain or sensory disturbances [1]

The combined effects of activating fibroblasts and endothelial cells are improved skin flexibility, improved wound healing, and decreases in fine lines and wrinkles

22 Whilst evidence is limited, it consistently reports a benefit of B12 for aphthous ulcers regardless of B12 status