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Proteomics 14:13431356 Acknowledgements The purchase of Synapt XS HDMS was financially supported by the Excellence InitiativeResearch University program for the University of Wroclaw

Also, SLC7A11 is negatively modulated by activating transcription factor 3 and p53 at the transcriptional level (Koppula et al., 2021a)

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Anastomosis and cysteamine colitis healing assessment was performed at day 3, 5, 7, and 14 as described before (5-7, 9-11, 42, 43), the stool formation (scored 1 or 2, unformed or formed), weight loss (, g, initial weight-post-surgery weight) and survival (number of survived and dead rats) were assessed initial as well