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Description

We showed that, on unfurling of the Munc18-1 loop, helix 11 and 12 in domain 3a bind to the central region of the VAMP2 SNARE motif, and validated its functional relevance in reconstituted assays and in living neurons

Introduction Ferroptosis is a distinct form of cell death characterized by iron-dependent, lipid peroxidation-driven, and accumulation of reactive oxygen species (ROS) [1]