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JAMA Surg 159(9):1087-1089, 2024

Thiol oxidative stress-dependent degradation of transglutaminase2 via protein S -glutathionylation sensitizes 5-fluorouracil therapy in 5-fluorouracil-resistant colorectal cancer cells

As discussed in other sections of this review, the first pass metabolism of oral products in the liver may increase inflammatory cytokines such as hsCRP and other coagulation proteins increasing risk of thrombosis in susceptible individuals (Brosnan et al., 2007