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Research from the Pickart era (1970s-2000s) established that GHK-Cu influences over 4,000 human genes toward healthier expression patterns, as documented in the International Journal of Molecular Sciences and related publications

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Surface mass balance (SMB) model output, calculated within the model code as precipitation minus evaporation (wind-related processes are not accounted for by HadCM3), are similarly evaluated against AnSMB (Wang et al., 2021), the most recent quality-controlled published SMB compilation extracted from stakes, snow pits, ice cores, ultrasonic sounders, and ground-penetrating radar