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Journal of Superconductivity and Novel Magnetism, 31 , 33973413

Hypoxic conditions induced the reductive metabolism of glutaminase in tumor cells, resulting in the transcriptional activation of GLS via HIF-1 upregulation [90]

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The compounds that were effective across multiple models were further tested as single agents and in combination with a clinically relevant protocol mimicking COJEC 12 , the five-chemotherapy cocktail (cisplatin, vincristine, carboplatin, etoposide and cyclophosphamide) that is the first line of action to treat HR-NB patients set by the International Society of Pediatric OncologyEuropean Neuroblastoma (SIOPEN) 6