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doi: 10.3390/ijms241612760 78

A major part of the systemic dose will form mixed disulphides together with serum albumin, while a minimal amount of the drug fractions will undergo hepatic metabolism to become disulphides

Since it is difficult to modify intrinsic GSH reactivity in the presence of cellular GST, warheads with reduced reactivity are preferred to minimize the non-specific covalent binding burden on proteins, which correlates with the in-vitro reaction rate of the drug and GSH [105,106]

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