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Alterations in the normal function of excitatory amino acid carrier 1 affect cysteine transport and GSH synthesis impairing zinc homeostasis (the thiol group of GSH can function as a principal Zn 2+ chelator for the maintenance of Zn 2+ homeostasis in neurons) and oxidative stress, enhancing susceptibility to ischemia-induced neuronal cell death in the hippocampus (162164)

In this paradigm, aquaporin 8 silencing, which is specifically expressed in IMM, enhances mitochondrial ROS generation and results in mitochondrial depolarization and cell death (Marchissio et al., 2012)

[DOI] [PubMed] [Google Scholar] 44.Betten DP, Cantrell FL, Thomas SC, Williams SR, Clark RF

This reactive stroma substantially modifies the mechanical and biochemical properties of the TME, creating a favorable condition that supports tumor growth and immune evasion