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A 2019 study found that older adults supplementing high doses of vitamin B12 were at an increased risk of colon cancer

3 In B12 deficiency, methylmalonic acid (MMA) can accumulate, and it is thought that elevated MMA, alongside elevated homocysteine, contributes to damage of the myelin sheath (which protects nerve cells and speeds up nerve transmission), which can cause irreversible neurological problems

They are chains of amino acids , also called the building blocks of proteins, that participate in many crucial psychological and biological processes

The classic symptoms of B12 deficiency are persistent fatigue, tingling or numbness in the hands and feet, problems with memory and concentration, mouth ulcers, a sore red tongue, and pale or yellow-tinged skin