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PD studies have shown a decline in kynurenic acid levels with elevation in 3-hydroxykynurenine levels favoring neurotoxic states in the frontal cortex, putamen and substantia nigra pars compacta brain regions (75, 77)

doi: 10.1016/j.nano.2014.09.004 290 LibbyP

Nat Rev Drug Discov 18 , 139158 (2019)

3D-hUMSCs exosomes ameliorate vitiligo by simultaneously potentiating treg cells-mediated immunosuppression and suppressing oxidative stress-induced melanocyte damage