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The benefits begin to be felt in a concrete way between the fourth and sixth session in a recommended program of about twelve treatments in six weeks (two sessions per week) with periodic maintenance calls ideally to be practiced every three to four weeks

As a result, although safer regimens have replaced many previous treatments in modern times, efforts to explore more efficient targeted therapies are ongoing

Different studies have also demonstrated that melatonin suppresses acrolein-induced IL-8 production in human pulmonary fibroblasts (Kim et al., 2012) and inhibits TGF-1-induced fibrogenesis in mouse lung fibroblasts (Zhao et al., 2018)

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