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Similarly, resistance to cisplatin can occur because of changes in processes (drug uptake, drug efflux, and/or intracellular drug sequestration) that prevent adequate levels of the drug reaching its DNA target, or by enhanced activity of processes that repair the DNA after it has been modified by the drug (Fig

And so that would be one reason why providers ought not to really sort of throw this at people without actually knowing more about this

Instead, the company focuses on purity, documentation, and consistency so that investigators can design their own protocols within institutional guidelines