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A well-executed prodrug strategy can effectively tackle various challenges in drug delivery, such as low solubility, instability, adverse effects, lack of specificity and poor cell uptake

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Contraindication(s) Since oral administration of acetylcysteine may result in vomiting or aggravate vomiting associated with acetaminophen overdosage, patients at risk of gastric hemorrhage (e.g., those with esophageal varices or peptic ulcers) should be evaluated with regard to the relative risks of upper GI hemorrhage and acetaminophen-induced hepatotoxicity and treatment with acetylcysteine given accordingly

B vitamins are also essential in cell repair and regrowth, among many other factors