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Recent drug discovery strategies are based on two criteria: first, compound structures that are distinct from bicalutamide and enzalutamide to avoid cross-resistance and, second, compounds that retain antagonist properties even for known AR mutant proteins that adopt agonist conformations when bound to current AR antagonists (also known as pan-antagonists)

The unreported variants were classified according to the American College of Medical Genetics (ACMG) criteria [32]

Defects in mtDNA replication challenge nuclear genome stability through nucleotide depletion and provide a unifying mechanism for mouse progerias

The codes reflect our interpretation of CPT coding requirements based upon AMA guidelines published annually