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Conversely, 6-TGNs were only associated with leukopenia in patients with IBD with NUDT15 nonvariants but not in patients with NUDT15 variants

A broader 2023 review of microneedle-mediated delivery put the overall range of reported pore-closure times from a few hours up to 72 hours, depending heavily on skin type, needle dimensions, occlusion, and formulation