most abundant glutathione transferase in liver Subnormal Serum Enzyme Levels: A Review of Pathophysiology and Clinical Significance Frontiers | Oxidative stress modulation

The GPx4 isoenzyme (PHGPx) protects against lipid peroxidation by reducing toxic lipid and fatty acid hydroperoxides, including derivatives of cholesterol, providing important neuroprotection (Guloyan 2020) Glutathione is crucial for regulating DNA synthesis and repair, stabilizing cell membranes, protecting cells and proteins from oxidation, modulating cell differentiation, quenching reactive oxygen and nitrogen species, facilitating neurotransmission, and supporting myelin maturation

Long-term human data beyond 6 months remains limited, but preclinical toxicology studies in animals showed no concerning findings with chronic administration

Both control and HF diet groups consumed similar amounts of food

Miao XP, Yang S, Tan W, Zhang XM, Ye YJ, Lin DX, Wang S