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When NNMT activity is high, NAD+ is depleted, metabolic rate slows, and fat accumulation increases

It is an intracellular metabolic-enzyme modulator, which is why its research read-outs are things like NAD+ levels and adipocyte gene expression, not how full you feel. That mechanistic distinction is the single most important thing to understand before looking at any dose number

Its the first monthly injection approved by the FDA for COPD