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For this reason, you should receive Epitalon only as part of a physician-supervised wellness program rather than administering it on your own

PLoS ONE 8 , e57247 (2013)

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of the human body

Not only would someone with a CBS up-regulation be losing methyl groups, as well as the primary antioxidant defense in every cell (glutathione), any additional methyl groups from diet or supplementation could cause a potential surge in CBS up-regulations