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Cells possess multiple mechanisms for internalization and particle uptake, including clathrin-mediated endocytosis, caveolin-mediated endocytosis, fluid-phase endocytosis, lipid raft endocytosis, and bulk endocytosis ( in vivo and enabling accurate nanoparticle aggregation at tumor locations ( 2.3 How next-generation nanoparticles address limitations of traditional drug delivery The active targeting of tumor cells has been a focal point since Paul Ehrlichs concept of the magic bullet in the early 1900s