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4C, we found that 722 genes were up-regulated and 1458 genes were down-regulated after the treatment of ZCQ

Copper serves as a cofactor for lysyl oxidase and lysyl hydroxylase, enzymes essential for collagen cross-linking and structural integrity

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Largely elevated levels of circulating IGF-I but as a result of absence of proteolysis of IGFBP-5 and IGFBP-3, necessary for disruption of ternary complex formation, IGF-I bioactivity in serum is low and presumably tissue bioactivity of IGF-I (and IGF-II) is low