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More recently, it has been demonstrated that NSC-34 cells expressing TDP-43 mutants also exhibit shortened neurites, increased OS, and decreased HO1 level, and these effects can be reversed by the UPS inhibitor MG132, but not by the Nrf2 activator sulforaphane [255, 256], probably because MG132 induction of HO1 is Nrf2 independent

Long-term impacts It is common and understandable for family members to have many questions about the long-term effects of the brain injury on the injured persons ability to function in the future

Collectively, these instances demonstrate the molecular diversity, clinical precedence, and potency amplification achievable through metal coordination

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