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However, all mutant TRIP13 caused the H2Ax (a classical DNA damage marker) signals accumulation (Figures 2C,D)

A sterile solution should have none

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Class IV Medications: Calcium Channel Blockade Class IV antiarrhythmic drugs exert their effects by blocking L-type calcium channels, with primary action at the sinoatrial (SA) and atrioventricular (AV) nodes (11)(21)(47)