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In 2017, China Xuanwu Hospital proposed the following diagnostic criteria for BTBGD [69]: (i) subacute onset in early childhood

The oxidized enzyme presents a selenenylsulfide motif in trans-configuration, with the selenium atom of Sec-498 positioned beneath the side chain of Tyr-116, thereby located far from the redox active moieties proposed to be involved in electron transport to the Sec-containing active site

Interestingly, this interaction is usually bidirectional, whereby immune cells also influence fibroblast behaviour ( in vitro cultures, Zhou et al

Karagiannidis C, Mostert C, Hentschker C, Voshaar T, Malzahn J, Schillinger G, et al