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Circadian Clocks and Cancer: Timekeeping Governs Cellular Metabolism

[165] See also References "Why Kyle Lowry Is the Greatest Toronto Raptor of All Time"

Cells were seeded in 96-well plates and treated with different concentrations of compounds for 3 days

Using the mutant GSTP-S184A and GSTP-S184D plasmids, we found that Ser184 phosphorylation is essential for GSTP to enter the nucleus and to inhibit cytoplasmic translocation of HMGB1 in LPS-activated macrophages, while the phosphorylation of GSTP at Ser42, Tyr3, Tyr7, and Tyr198 is unnecessary