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Short-term GHK-Cu use (weeks to few months) typically shows benefits gradually declining toward baseline over 2-4 months post-discontinuation as newly synthesized collagen undergoes normal degradation without replacement at treatment-stimulated rates

Primary endpoints should center on pain and function Knee Injury and Osteoarthritis Outcome Score (KOOS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Patient-Reported Outcome Measurement Information System (PROMIS) scores), structure (MRI evaluation with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) when appropriate), and time to milestones (return to sport)

This is what's used on supplement labelling, where the vitamin B12 content is given in mcg and as a percentage of the NRV

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