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In this process, a vital role in causing considerable harm to the Schwann cells and neurons in the peripheral nervous system is played by pro-inflammatory cytokines produced by cells that are resident or have infiltrated [26]

Studies conducted by Khavinson's team and collaborating groups have suggested epithalon may modulate telomerase activity in human cell lines, with reactivation observed in some senescent fibroblasts and telomere extension measured by Southern blot or qPCR

Inflammatory cytokines and mediators, including TNF-, IL-1, PGE2, IL-6, and VEGF, TGF-1, are among the tumor-associated factors that promote MDSC proliferation, expansion, and differentiation [31]

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