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Activated Th1 and Th17 cells produce inflammatory products and cytokines that disrupt myelin and axons and activate retained microglia, which in turn generate inflammatory cells that attract more inflammatory cells to the central nervous system (CNS) and perpetuate the inflammatory cascade ( in vitro and in mouse EAE (82)

Sonic hedgehog signaling instigates high-fat diet-induced insulin resistance by targeting PPAR stability

The same exosomes also remodel the microbiota-metabolite network, upregulate FXR expression, restore barrier integrity, and reduce colitis inflammation [478], thus linking immune suppression with microecological repair into a closed-loop

Proper refrigeration will maintain its stability and potency for several weeks