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These autoantibodies are hypothesised to target nuclear, membrane, and neurotransmitter receptor structures (255)

The risk is greatest among infants who are fed formula low in biotin, people taking antiepileptic medications, infants with Leiners disease or people who are genetically predisposed to deficiency ( Untreated biotin deficiency can cause neurological symptoms, such as seizures, intellectual disability and loss of muscle coordination ( Deficiency has also been reported in animals fed high amounts of raw egg whites

Exclusion criteria included non-rodent species, animal models centered on general neurological or psychiatric conditions not specific to ASD, and non-pharmacological or non-gut microbiota interventions (behavioral, dietary, device, surgical, herbal only)

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