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Inflammation: Excessive sugar and unhealthy fats promote the release of pro-inflammatory cytokines in the brain, leading to neuroinflammation, which is linked to impaired memory and learning as well as an increased risk of neurodegenerative diseases

There is a gender-specific association between hypothyroidism and cholelithiasis, and males with gallstones should be screened for thyroid conditions

Moreover, structural and functional intestinal alterations arising from a lack of diversity in the microbiome have shown a correlation with increased heart failure related risk and incidence (Velasquez et al., 2016)