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The BBB in Parkinson's disease The pathophysiology of Parkinson's disease involves various potential pathways that can progressively worsen over time, leading to symptoms such as body tremors, muscle stiffness, unsteady gait, and difficulties with physical balance and coordination[45] (Fig

Cell Mol Gastroenterol Hepatol (2022) 15(4):887901

Patients with GT-D virus had the lowest mean HBsAg level at baseline (2.97 log IU/mL) and GT-B the highest (3.76 log IU/mL)

The mechanism of action involves the formation of a ternary complex between the PROTAC, the target protein, and the E3 ubiquitin ligase, leading to polyubiquitination and subsequent proteasomal degradation of the target protein [37,38,39,40]