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Prevention and Management of Osteoporosis: Report of a WHO Scientific Group

This review critically interrogates the mechanistic interface between remediation and toxicity

19.2.4 Resistance Caused by Decreased Drug Activation or Increased Drug Inactivation Many antineoplastic drugs, and in particular the antimetabolites, must be converted to a pharmacologically active form after cellular uptake in order to exert their cytotoxic effects (see Chap

Such enlargement results in a diminished ability of the heart to contract effectively , leading to reduced pumping efficiency and potentially triggering heart failure, fluid accumulation in the lungs (pulmonary edema), and other life-threatening complications