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TIGAR inhibit glycolysis and improve PPP as compensation, resulting in increased NADPH production, which helps to limit ROS (Bensaad et al., 2009

Week 1: begin 1 gram daily to check tolerance

Conversely, in FD ECM and myofibroblasts generally attract smaller infiltrates of predominantly macrophages and granulocytes through specialized chemo-, hapto- and durotactic gradients and growth factors for these cells